Ethnicity and outcomes for patients with gastrointestinal disorders attending an emergency department serving a multi-ethnic population

Background Ethnic inequalities in acute health acute care are not well researched. We examined how attendee ethnicity influenced outcomes of emergency care in unselected patients presenting with a gastrointestinal (GI) disorder. Methods A descriptive, retrospective cohort analysis of anonymised patient level data for University Hospitals of Leicester emergency department attendees, from 1 January 2018 to 31 December 2021, receiving a diagnosis of a GI disorder was performed. The primary exposure of interest was self-reported ethnicity, and the two outcomes studied were admission to hospital and whether patients underwent clinical investigations. Confounding variables including sex and age, deprivation index and illness acuity were adjusted for in the analysis. Chi-squared and Kruskal–Wallis tests were used to examine ethnic differences across outcome measures and covariates. Multivariable logistic regression was used to examine associations between ethnicity and outcome measures. Results Of 34,337 individuals, median age 43 years, identified as attending the ED with a GI disorder, 68.6% were White. Minority ethnic patients were significantly younger than White patients. Multiple emergency department attendance rates were similar for all ethnicities (overall 18.3%). White patients had the highest median number of investigations (6, IQR 3–7), whereas those from mixed ethnic groups had the lowest (2, IQR 0–6). After adjustment for age, sex, year of attendance, index of multiple deprivation and illness acuity, all ethnic minority groups remained significantly less likely to be investigated for their presenting illness compared to White patients (Asian: aOR 0.80, 95% CI 0.74–0.87; Black: 0.67, 95% CI 0.58–0.79; mixed: 0.71, 95% CI 0.59–0.86; other: 0.79, 95% CI 0.67–0.93; p < 0.0001 for all). Similarly, after adjustment, minority ethnic attendees were also significantly less likely to be admitted to hospital (Asian: aOR 0.63, 95% CI 0.60–0.67; Black: 0.60, 95% CI 0.54–0.68; mixed: 0.60, 95% CI 0.51–0.71; other: 0.61, 95% CI 0.54–0.69; p < 0.0001 for all). Conclusions Significant differences in usage patterns and disparities in acute care outcomes for patients of different ethnicities with GI disorders were observed in this study. These differences persisted after adjustment both for confounders and for measures of deprivation and illness acuity and indicate that minority ethnic individuals are less likely to be investigated or admitted to hospital than White patients. Supplementary Information The online version contains supplementary material available at 10.1186/s12916-024-03490-0.


Background
Identifying and driving down health inequalities is a key goal as set out in the NHS Long Term Plan [1].Ethnic inequalities in health are well described in the UK, where individuals from minority ethnic backgrounds generally experience worse health outcomes than White British people [2].This is particularly true for long term conditions such as type 2 diabetes and cardiovascular diseases which disproportionately affect South Asian individuals [3][4][5][6][7].The evidence for ethnicity-related inequalities in acute care is less well researched, but studies of emergency hospital admissions indicate a complex relationship between ethnicity and the risk of admission where non-White patients tend to be younger and experience a lower mortality risk than White patients [8], but with ethnic minorities being at higher risk of admission for some illnesses [9].
The underlying causes of these ethnic differences in health outcomes are complex and poorly understood with a variety of potentially contributing and intersecting factors such as multiple long-term conditions and social determinants of health.It is important for providers of acute care to identify and investigate differences in the processes of care and their outcomes for all users of their services to enable the effective planning of care pathways and the appropriate targeting of healthcare interventions to all sectors of the community.
Gastrointestinal (GI) disorders represent the second most common classifiable diagnoses in patients presenting to English hospital Accident and Emergency Departments (ED) (fractures/dislocations/joint injuries being the most common) [10], and their assessment and treatment is associated with high healthcare costs.
Therefore, as part of a Trust-wide programme of clinical service inequality analyses, we examined how attendee ethnicity influenced outcomes related to the processes of acute emergency care, focusing on unselected patients of various ethnicities with presenting to the ED at a busy acute Trust in England with a GI disorder.

Methods
University Hospitals of Leicester NHS Trust (UHL) provides acute care services to a population of over 1.2 million across Leicester, Leicestershire and Rutland [11].This population is ethnically diverse such that within the City of Leicester, more than 50% of residents have a minority ethnic background, with the highest number being of South Asian heritage [12].In contrast, the surrounding County of Leicestershire population is of 87.5% White ethnicity [13].The Accident and Emergency Department (ED) at UHL had around 242,000 attendances in the 12 months from the beginning of January to the end of December 2019.

Study design and data source
In this descriptive, retrospective cohort study, anonymised patient level data were extracted from the hospital's electronic data systems.A fully anonymised dataset was then provided to the investigators.This analysis of anonymised, routine patient data was approved by the UHL Data Protection Officer/Head of Privacy and registered as a service evaluation by the UHL Clinical Audit and Effectiveness Team (reference number 11675).We conducted and reported this service evaluation following the RECORD (REporting of studies Conducted using Observational Routinely Collected Data (RECORD) checklist (Additional file 1: Table S1) [14].

Study population
All patients who attended the UHL ED and received a coded diagnosis for a gastrointestinal or hepatobiliary illness (hereafter referred to as a 'GI disorder' , see Additional file 1; Table S2 for diagnostic codes included) in the electronic patient record (EPR) between 1 January 2018 and 31 Dec 2021 were identified and formed the cohort population.Specified patient level data for this cohort (see below) were then extracted from the UHL data warehouse.For patients with multiple attendances for with a GI disorder in this period, the number of attendances was recorded, but only the first attendance was studied.Sociodemographic factors (age and sex) were extracted along with the day and time of ED attendance and the length of time in the ED.The date of attendance at the ED was collapsed into year of attendance (2018 to 2021).

Exposure, outcomes and covariables
The primary exposure of interest was patient selfreported ethnicity.Codes for self-reported ethnicity recorded in the EPR (Additional file 1; Table S3) were used to derive a five-level ethnicity variable using the same broad ethnic groupings as the UK Office for National Statistics: White, Black, Asian, mixed, or other [15].Initial dynamic priority score (DPS) and initial early warning scores were extracted as measures of acuity of illness presentation.
Two outcomes were evaluated for their association with ethnicity, firstly whether the patient was admitted to hospital after presentation to the ED (binary variable: admitted [1] vs not admitted [0]) and secondly whether the patient underwent any clinical investigations in the ED (binary variable: underwent any investigation [1] vs did not undergo any investigations [0]).For a list of investigations and procedures, see Additional file 1: Table S3.
Data describing variables which could potentially confound the relationship between ethnicity and decisions relating to hospital admission or investigation were also collected.These included sex and age at presentation (categorised into 0-17 years, 18-29 years, 30-59 years, ≥ 60 years).We collected data relating to breaches of the national 4-h emergency department waiting time target [16].Deprivation in residential areas was determined using the index of multiple deprivation (IMD) derived from the patient postcode.The IMD is the official measure of relative deprivation for England [17] where small residential areas are ranked based on 7 domains (income, employment, education, health, crime, barriers to housing/services and living environment).Ranks were collapsed into quintiles.Severity of illness on presentation as measured by the National Early Warning Score [18] or Paediatric Early Warning Score [19] (hereafter referred to as EWS) on presentation to the ED.The EWS is an aggregate scoring system used to classify the severity of an acute illness based on routinely gathered physiological parameters.We also collected the DPS assigned to every ED attendee as a local prioritisation system [20].
We produced descriptive statistics for some additional common NHS metrics including number of four-hour breaches and ED waiting times to fully describe the underlying data.These metrics were not used as outcome measures in the adjusted analyses to avoid overlap between factors associated with total time in ED and decisions to admit.

Statistics
Categorical variables were summarised as frequency and percentage and continuous variables as median and interquartile range (IQR).Chi-squared tests and Kruskal-Wallis tests were used to examine ethnic differences across outcome measures and covariates for categorical and continuous variables respectively.The number of ED attendances were plotted against the number and proportion of patients admitted over the study period.
Multivariable logistic regression was used to examine the association between ethnicity and our binary outcome measures and present results as adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs).Three models were constructed for each outcome: model 1 was adjusted for age, sex and year of attendance; model 2 included all variables in model 1 plus EWS; model 3 included all variables in model 2 plus IMD quintile.This sequential adjustment was undertaken to examine whether ethnic differences in severity at presentation and/or deprivation might explain any age/sex adjusted associations between ethnicity and our outcome measures.
The frequency and proportion of observations with missing data was calculated in each of the variables used in the analysis.Multiple imputation by chained equations to impute missing covariate data was used in all logistic regression models.Imputation models contained all variables used in the analysis except the one being imputed, including the outcome measures.Rubin's Rules were used to combine parameter estimates and standard errors from 10 imputations into a single set of results [21].To investigate the impact of using multiple imputation on our results, a sensitivity analysis was undertaken using listwise deletion, excluding those with missing covariate data in any variable used in the models.
All analyses were conducted using Stata

Cohort characteristics
In total, there were 46,602 visits to the ED with a GI disorder in the study period.After exclusion of repeat attendances, 34,337 individuals were identified as attending the ED with a GI disorder with fully coded ethnicity and admission data, of whom 34,296 had complete data for ethnicity and investigations (Fig. 1).Baseline characteristics and demographics of the cohort are shown in Table 1.Ethnicity coding was complete for most attendees in the study period with 1049 (2.9%) attendees having missing or 'not stated' ethnicity data.Of those with coded ethnicity, 23,548 (68.6%) were White, 7450 (21.7%) were Asian, 1410 (4.1%) were Black, 722 (2.1%) were of mixed ethnicity and 1207 (3.5%) reported other ethnicities.
The median age of attendees was 43 years (IQR 23-67 years), but patients from minority ethnic groups were significantly younger (p < 0.001,Table 1 Females comprised 55.7% of all attendees with a similar pattern across all ethnic groups.Minority ethnic attendees were significantly more likely to be from the most deprived areas (p < 0.001, Table 1), whereas White attendees were more equally distributed across all groups of deprivation.
The ).In terms of acuity of presentation, White patients presented with significantly higher illness acuity than ethnic minority patients, as measured by both EWS and DPS (p < 0.001, Table 1).

ED attendance patterns across the study period
The pattern of ED attendances by patients with GI disorders is shown in Fig. 2.There was a steep decline in the overall numbers of both attendances and admissions before the first national UK lockdown in March 2020.These numbers were still lower at the end of 2021 compared to pre-pandemic levels.However, the proportion of patients admitted showed little change.
Multiple attendances were recorded for 18.3% of all attendees (Table 1).However, there were no significant differences in the rate of multiple attendances between the different ethnic groups.

Factors influencing performance of clinical investigations
Overall, 29,887 (87.0%) attendees with an GI disorder underwent some form of clinical investigation into their presenting illness (see Additional file 1: Table S3 for investigations studied).
Children below the age of 18 years of age were significantly less likely to be investigated than older patients (aOR 0.18, 95% CI 0.16-0.20 vs patients aged 18 to 29 years, p < 0.0001), and males were less likely to be investigated than females (aOR 0.70, 95% CI 0.65-0.75,p < 0.0001) as most females with abdominal symptoms will have a pregnancy test (Additional file 1: Figure S1 and Table S4).There was a general trend such that the aOR for receiving investigations was inversely related to level of deprivation.The least deprived (those from IMD quintile 5) were significantly more likely and the most Fig. 2 Monthly attendances and admissions for patients with GI disorders over the study period Fig. 3 Logistic regression models showing the relationship between ethnicity with having investigations performed following attendance at the emergency department with GI disorders.Figure 3 shows the adjusted odds ratios and 95% confidence intervals for the relationship between ethnicity with undergoing any investigations after presentation to the emergency department with abdominal pain (n = 34,296) using the imputed dataset.Three models were constructed; the first (blue) is adjusted for age, sex and the year of first attendance at the ED with abdominal pain during the study period.The second (red) is additionally adjusted for EWS.The third (green) is additionally adjusted for the IMD quintile.Estimates are represented by dots and the 95% confidence interval for the estimate by bars.EWS, early warning score; IMD, index of multiple deprivation; Ref, reference level deprived (IMD quintile 1) were significantly less likely to have investigations than those from IMD quintile 3 (IMD quintile 5: 1.16, 95% CI 1.01-1.32,p = 0.03; IMD quintile 1: 0.88, 95% CI 0.78-0.99,p = 0.03) (Additional file 1: Figure S1 and Table S4).

Factors influencing discharges and admissions to hospital
Of the 34,337 patients attending the ED with GI disorders 18,972 (55.3%) were admitted to hospital.Amongst those admitted, median (IQR) ages for each ethnic group were as follows: White: 57 years ( 32 The numbers of such attendees declined sharply in early 2020 corresponding to the start of the COVID-19 pandemic (Fig. 2).There was an accompanying reduction in the number of individuals with GI disorders admitted to the hospital from the ED over this period.Attendees were significantly less likely to be admitted in 2020 and 2022 compared to 2018 and 2019 (Additional file 1: Figure S2 and Table S5).
Minority ethnic patients presenting with GI disorders tended to have lower initial EWS and a lower priority DPS than White attendees and were significantly less likely to be admitted to hospital than White patients (p < 0.001, Table 1).However, when analyses were adjusted for the variables-age, sex, year of attendance, EWS and IMD quintile-minority ethnic attendees were significantly less likely than those from White ethnic groups to be admitted to hospital in all models tested (in the fully adjusted model, Asian: aOR 0.63, 95% CI 0.60-0.67;Black: 0.60, 95% CI 0.54-0.68;mixed: 0.60, 95% CI 0.51-0.71;other: 0.61, 95% CI 0.54-0.69;p < 0.0001 for all) (Fig. 4 and Additional file 1: Table S5).Using patients aged 18-29 years as a reference group, children were significantly less likely to be admitted and older patients significantly more likely to be admitted to hospital (0 to 17 years: aOR 0.59, 95% CI 0.55-0.64,≥ 60 years: 2.53, 95% CI 2.36-2.71;p < 0.0001 for both) (Additional file 1: Figure S2).There was no significant difference in the odds of admission between males and females after adjustment (Additional file 1: Figure S2 and Table S5).Those living in the most deprived IMD quintile were significantly less likely to be admitted to hospital than those in quintile 3 (aOR 0.90, 95% CI 0.83-0.97;p = 0.005) (Additional file 1: Figure S2 and Table S5).
In a sensitivity analysis using observations with complete case data, our findings were largely unchanged (Additional file 1: Figures S3 and S4).  4 Logistic regression models showing the association between ethnicity and admission following attendance at the emergency department with GI disorders.Figure 4 shows the adjusted odds ratios and 95% confidence intervals for the relationship between ethnicity and admission to hospital after presentation to the emergency department with abdominal pain (n = 34,337) using the imputed dataset.Three models were constructed; the first (blue) is adjusted for age, sex and the year of first attendance at the ED with abdominal pain during the study period.The second (red) is additionally adjusted for EWS.The third (green) is additionally adjusted for the IMD quintile.Estimates are represented by dots and the 95% confidence interval for the estimate by bars.x axis is on a log scale.EWS, early warning score; IMD, index of multiple deprivation; Ref, reference level

Discussion
Considerable evidence describes health inequalities related to ethnicity [3][4][5][6][7]22] and several studies demonstrate racial and ethnic disparities in emergency medicine [23][24][25][26]; however in the UK, there has been little focus on inequalities in acute hospital care.To our knowledge, this is the largest analysis of outcomes for ED attendees with GI disorders broken down by ethnic group.The chosen outcome measures, directly related to the process of care in the ED, were the frequency of patients with such disorders receiving the clinical investigations common in this clinical setting or the likelihood of being admitted to hospital after ED assessment.We looked at patient-level data from attendances at a busy ED in England including the 2 years before and the nearly 2 years after the commencement of the COVID-19 pandemic and found significant differences in the patterns of usage and disparities in care and outcomes for patients of different ethnicities with GI disorders.Statistical adjustment for potentially confounders, including socioeconomic factors and differences in illness acuity, attenuated but did not eliminate these apparent disparities, with non-White individuals remaining less likely to be investigated or admitted when found to have a GI disorder.
Ethnicity was generally extremely well-coded, better than has been previously observed in English hospitals [27], and the proportion of attendees from non-White backgrounds was higher than that observed for the population across England overall, in keeping with local population demographics [12].Minority ethnic attendees tended to be younger than White attendees, most likely explained by the minority ethnic populations in Leicester being generally younger than the White population, although differences in access to healthcare services and cultural attitudes may also contribute.The data also show a significant dip in absolute numbers of patients attending with a GI disorder during and post-COVID which had not fully recovered by the end of 2021.This pattern reflects the overall ED activity levels reported across England post-COVID [28].
Both the initial DPS assigned using a local prioritisation system to determine the required urgency of intervention or secondary assessment and the initial EWS [18,19] measured in attendees on arrival at the ED were utilised to assess the impact of illness acuity on patient outcomes.By both measures, minority ethnic patients were generally assessed as lower clinical priority than White attendees on arrival at the ED.This observation, and that of minority ethnic patients having shorter time spent in ED, is consistent with a higher proportion of minority ethnic patients being younger and likely attending ED with less serious conditions.However, caution is required in interpreting this non-adjusted data since severity of illness at presentation and likelihood of admission will impact on time spent in ED.
We found lower illness acuity scores in those from ethnic minority groups.However, after adjusting for EWS, rather than DPS because the former score is more widely validated, and other covariables including age, sex and deprivation index, minority ethnic patients remained significantly less likely to be investigated or admitted to hospital than White people for the same types of illness.The reasons are unclear but may relate to cultural differences in illness presentation and healthcare-seeking behaviour between ethnic groups [29,30].Disparities in emergency care have previously been described in the US and Australia, where Black or indigenous patients in the ED are less likely to receive clinical imaging investigations and analgesia for acute pain than Whites [23][24][25][26].The bulk of evidence on healthcare outcome inequalities focuses on ethnicity, sex and socioeconomic status [31,32]; however, when we corrected for both sex and socioeconomic status, racial disparities remained in the current study.Others have attributed such disparities, in part, to implicit bias in the assessment by the healthcare provider [33,34], although we have no evidence for this and cannot correct for it as a covariable.Underlying reasons are likely to be complex.Differences between ethnic groups in the presentation of illness, the language used to describe symptoms and in illness behaviour are well recognised [29,30].Generalised musculoskeletal pain is more common in South Asian individuals in the UK [35].South Asians with acute coronary syndromes report pain over a larger area of their bodies than White ethnicities [36] and display a greater tendency to seek immediate care [37].Presentations to ED with GI disorders may also potentially be driven by these factors.
There may also be a mismatch between the clinician's and the patient's mental model of disease which impairs communication.Use of language is important in the clinician/patient interaction, but English proficiency is not recorded, so it could not be used as a covariate.Cultural alignment between clinician and patient might also impact the quality of the clinical consultation.Given all of these potential causes of bias, it is reassuring that minority ethnic individuals did not experience a higher rate of ED re-attendance and so were not being discharged prematurely with an illness that subsequently required further assessment or treatment in the future.
The implication might be that White patients were being over-admitted rather than minority ethnic patients being under-admitted.Over-investigation and overtreatment of patients in healthcare is widely recognised, including in emergency medicine [38].Decisions guiding the investigation and admission of patients may be driven by multiple factors beyond assessment of acuity of presentation, but being subjected to unnecessary investigations or being admitted to hospital unnecessarily would be negative healthcare outcomes, particularly for older people [39,40].Lower rates of diagnostic investigations and admissions in the non-White patients may potentially result from these significantly younger individuals having greater engagement in decision making about their care, and with parents able to care for children, coupled with a reluctance on the part of medical staff to discharge the more elderly White patients home from the ED due to a lack of social support.
The strengths of the current analysis include the assembly a large, well-defined cohort, longitudinal over 4 years pre-and post-COVID-19 pandemic, assessed and treated using consistent and standardised processes and the ability to adjust for multiple covariables including illness acuity by two different methods.The wide range of underlying clinical conditions and large differences in age and severity might make severity adjustment incomplete, leaving residual confounding.Data completeness was good and patient ethnicity was reliably collected and very well coded in clinical systems, although aggregated ethnicity categories may not reflect intra-group heterogeneity.That the data are derived from a single centre is a potential limit to generalisability.Data relating to attendees' presenting symptoms and any co-morbidities were also not available but could have helped interpretation of the findings.Patient disease outcomes (recovery from disease and associated healthcare costs) were not available, so no conclusions could be reached about the effects of the disparities found.Future research will examine disease outcomes for this cohort to enable further understanding of the differences found in this analysis.
We also did not explore interactions between variables such as age and ethnicity as part of this work as this would lack statistical power for detecting differences in outcomes for the smaller groups, thus increasing the risk of type II error.However, future work with a larger sample, or with a more equal distribution across ethnic groups, should explore interactions, especially those between age and/or illness severity with ethnicity.

Conclusions
The current analysis reveals important new information about differences in the outcomes of acute care for patients from different ethnic groups treated in a single centre.The explanation for these differences is likely to be complex and will require future research to fully elucidate.This will require analysis of whether differences in the processes of care lead to different disease outcomes, by using linked primary and secondary care data and qualitative analyses of attitudes and experiences of both the patients accessing acute care and the staff providing their care.

Fig.
Fig.4 Logistic regression models showing the association between ethnicity and admission following attendance at the emergency department with GI disorders.Figure4shows the adjusted odds ratios and 95% confidence intervals for the relationship between ethnicity and admission to hospital after presentation to the emergency department with abdominal pain (n = 34,337) using the imputed dataset.Three models were constructed; the first (blue) is adjusted for age, sex and the year of first attendance at the ED with abdominal pain during the study period.The second (red) is additionally adjusted for EWS.The third (green) is additionally adjusted for the IMD quintile.Estimates are represented by dots and the 95% confidence interval for the estimate by bars.x axis is on a log scale.EWS, early warning score; IMD, index of multiple deprivation; Ref, reference level 17 (StataCorp.2017.Stata Statistical Software: Release 17.0 College Station, TX: StataCorp LLC).

Table 1 .
Description of the cohort stratified by ethnic group DPS Dynamic priority score, IMD Index of multiple deprivation, IQR Interquartile range, EWS Early warning score * Describes only those with complete ethnicity data.Those with missing ethnicity data and those coded as 'not stated' are excluded (N = 1049) † Comparison between ethnic groups was by chi-squared test for categorical variables and by Kruskal-Wallis test for continuous variables